Here is a simple comparison between using a Nova Launcher and HTC Sense. When using Nova Launcher, music is played using Google Play Music because I can play it using widgets on home screen. But once I off the screen, you will realize that I need to unlock the screen if I want to pause or skip the music.
With HTC Sense, music can be played using default player as widgets available on home screen. And once I turn on the screen, I do not need to unlock the screen to pause or skip tracks.
HTC - The Smartphones that make Sense.